Abstract
A new diimide derivative, named (-)-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthesis. Primary bioassays showed that 1 had weak cytotoxic activity against Hep-2 and HepG2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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China
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Drug Screening Assays, Antitumor
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Fungi / chemistry*
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Furans / chemistry
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Furans / isolation & purification
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Hep G2 Cells
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 3-Ring / pharmacology
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Humans
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Imides / chemistry
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Imides / isolation & purification*
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Imides / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
Substances
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Antineoplastic Agents
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Furans
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Heterocyclic Compounds, 3-Ring
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Imides
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byssochlamic acid bisdiimide
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byssochlamic acid