Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles

Am J Psychiatry. 2010 Nov;167(11):1339-48. doi: 10.1176/appi.ajp.2010.09121731. Epub 2010 Sep 15.

Abstract

Objective: Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. While slow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated by thalamo-reticular and thalamo-cortical circuits. In a recent high-density EEG study, the authors found that 18 medicated schizophrenia patients had reduced sleep spindles, compared with healthy and depressed subjects, during the first non-REM episode. In the present study, the authors investigated whether spindle deficits were present in a larger sample of schizophrenia patients, were consistent across the night, were related to antipsychotic medications, and were suggestive of impairments in specific neuronal circuits.

Method: Whole-night high-density EEG recordings were performed in 49 schizophrenia patients, 20 nonschizophrenia patients receiving antipsychotic medication, and 44 healthy subjects. In addition to sleep spindles, several parameters of slow waves were assessed.

Results: Schizophrenia patients had whole-night deficits in spindle power (12-16 Hz) and in slow (12-14 Hz) and fast (14-16 Hz) spindle amplitude, duration, number, and integrated activity in the prefrontal, centroparietal, and temporal regions. Integrated spindle activity and spindle number had the largest effect sizes (effect size: ≥ 2.21). In contrast, no slow wave deficits were found in schizophrenia patients.

Conclusions: These results indicate that spindle deficits can be reliably established in schizophrenia, are stable across the night, are unlikely to be due to antipsychotic medications, and point to deficits in the thalamic reticular nucleus and thalamo-reticular circuits.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use
  • Brain Mapping
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiopathology
  • Electroencephalography*
  • Evoked Potentials / drug effects
  • Evoked Potentials / physiology
  • Female
  • Humans
  • Intralaminar Thalamic Nuclei / drug effects
  • Intralaminar Thalamic Nuclei / physiopathology
  • Male
  • Middle Aged
  • Nerve Net / drug effects
  • Nerve Net / physiopathology
  • Psychiatric Status Rating Scales
  • Reference Values
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Signal Processing, Computer-Assisted*
  • Sleep / physiology*
  • Thalamus / physiopathology*
  • Young Adult

Substances

  • Antipsychotic Agents