Abstract
We report a case of meningitis due to Lactobacillus rhamnosus in a child undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia. Four episodes of bacteremia involving strains with pulsotypes identical to that of the cerebrospinal fluid isolate preceded meningitis. After several courses of clindamycin, no relapse occurred during the patient follow-up.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / complications*
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Bacteremia / microbiology
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Bacterial Typing Techniques
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Cerebrospinal Fluid / microbiology
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Child
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Clindamycin / therapeutic use
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Electrophoresis, Gel, Pulsed-Field
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Genotype
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Gram-Positive Bacterial Infections / diagnosis*
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Gram-Positive Bacterial Infections / drug therapy
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Gram-Positive Bacterial Infections / microbiology
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Hematopoietic Stem Cell Transplantation
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Humans
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Immunocompromised Host*
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Lacticaseibacillus rhamnosus / classification
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Lacticaseibacillus rhamnosus / genetics
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Lacticaseibacillus rhamnosus / isolation & purification*
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Male
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Meningitis, Bacterial / diagnosis*
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Meningitis, Bacterial / drug therapy
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Meningitis, Bacterial / microbiology
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Molecular Sequence Data
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
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RNA, Ribosomal, 16S / genetics
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Recurrence
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Sequence Analysis, DNA
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Transplantation, Homologous
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 16S
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Clindamycin