Abstract
Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Cell Proliferation
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Cell Transformation, Neoplastic / immunology
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Colitis / immunology*
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Colitis / pathology
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Colonic Neoplasms / immunology*
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Colonic Neoplasms / pathology
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Humans
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Inflammatory Bowel Diseases / immunology*
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Inflammatory Bowel Diseases / pathology
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Lymphocyte Activation / immunology
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Mice
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Th17 Cells / immunology
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Transforming Growth Factor beta / immunology*
Substances
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Transforming Growth Factor beta