Direct carbon-carbon bond formation via reductive soft enolization: a kinetically controlled syn-aldol addition of α-halo thioesters and enolizable aldehydes

J Am Chem Soc. 2010 Oct 13;132(40):13997-9. doi: 10.1021/ja1057407.

Abstract

The direct addition of enolizable aldehydes and α-halo thioesters to produce β-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the unusual feature of giving high syn-selectivity, which is the opposite of that produced for (thio)esters under conventional conditions. Moreover, excellent diastereoselectivity results when a chiral nonracemic α-hydroxy aldehyde derivative is used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Carbon / chemistry*
  • Esters / chemistry*
  • Kinetics
  • Oxidation-Reduction

Substances

  • Aldehydes
  • Esters
  • Carbon