Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6182-4. doi: 10.1016/j.bmcl.2010.08.124. Epub 2010 Sep 16.

Abstract

A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, (99m)Tc-HYNIC-Bombesin((7-14)) could be used as an agent for tumor diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anura
  • Bombesin / analogs & derivatives*
  • Bombesin / chemistry
  • Carcinoma, Ehrlich Tumor / diagnostic imaging
  • Carcinoma, Ehrlich Tumor / metabolism
  • Indicators and Reagents
  • Injections, Intravenous
  • Mice
  • Mice, Inbred BALB C
  • Muscle, Skeletal / metabolism
  • Neoplasms / diagnostic imaging*
  • Organotechnetium Compounds / chemical synthesis*
  • Organotechnetium Compounds / pharmacokinetics
  • Peptide Fragments / chemical synthesis*
  • Peptide Fragments / pharmacokinetics
  • Radionuclide Imaging
  • Radiopharmaceuticals* / chemical synthesis
  • Radiopharmaceuticals* / pharmacokinetics
  • Spectrometry, Mass, Electrospray Ionization
  • Technetium*
  • Tissue Distribution

Substances

  • Indicators and Reagents
  • Organotechnetium Compounds
  • Peptide Fragments
  • Radiopharmaceuticals
  • technetium 99m HYNIC-bombesin (7-14)
  • Technetium
  • Bombesin