Abstract
The most common genetic predisposition to multiple schwannoma growth is mutation of the neurofibromatosis type 2 gene. We describe a patient with multiple schwannomas and mutation in the recently described INI1 gene, which also predisposes to the disease. We explore the implications for prognosis and outcome.
MeSH terms
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Aged
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Chromosomal Proteins, Non-Histone / genetics*
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DNA-Binding Proteins / genetics*
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Genetic Predisposition to Disease / genetics
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Humans
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Magnetic Resonance Imaging
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Male
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Mutation / genetics*
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Neurilemmoma / genetics
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Neurilemmoma / surgery
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Neurofibromatoses / genetics
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Neurofibromatoses / surgery
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Neurofibromatosis 2 / genetics*
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Neurofibromatosis 2 / surgery
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Prognosis
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SMARCB1 Protein
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Skin Neoplasms / genetics
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Skin Neoplasms / surgery
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Transcription Factors / genetics*
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Treatment Outcome
Substances
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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SMARCB1 Protein
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SMARCB1 protein, human
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Transcription Factors