[Toxicity of matrine in Kunming mice]

Nan Fang Yi Ke Da Xue Xue Bao. 2010 Sep;30(9):2154-5.
[Article in Chinese]

Abstract

Objective: To investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.

Methods: Matrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.

Results: The acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg (95%CI, 88.08-280.31 mg/kg). Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice.

Conclusion: The nervous system is the main target organ by the toxicity of matrine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / toxicity*
  • Animals
  • Brain / drug effects
  • Brain / pathology*
  • Female
  • Lethal Dose 50
  • Male
  • Matrines
  • Mice
  • Quinolizines / toxicity*
  • Toxicity Tests, Acute

Substances

  • Alkaloids
  • Quinolizines
  • Matrines