Palladium-catalyzed amination of unprotected halo-7-azaindoles

Org Lett. 2010 Oct 15;12(20):4438-41. doi: 10.1021/ol101928m.

Abstract

Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Catalysis
  • Indoles / chemistry*
  • Ligands
  • Molecular Structure
  • Palladium / chemistry*

Substances

  • 7-azaindole dimer
  • Indoles
  • Ligands
  • Palladium