Abstract
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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Guanine / chemistry*
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Molecular Sequence Data
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Oligonucleotides / genetics
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Optical Phenomena
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Spectrometry, Fluorescence
Substances
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Nucleosides
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Oligonucleotides
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Guanine