Synthesis of N-substituted Clausenamide analogues

Eur J Med Chem. 2010 Nov;45(11):5531-8. doi: 10.1016/j.ejmech.2010.08.041. Epub 2010 Aug 24.

Abstract

A practical synthesis of N-substituted Clausenamide analogues, including (-) and (+) CM1, Piracetam analogue 1 and Nefiracetam analogue 2, have been developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Lactams / chemical synthesis*
  • Lactams / chemistry
  • Lignans / chemical synthesis*
  • Lignans / chemistry
  • Long-Term Potentiation
  • Magnetic Resonance Spectroscopy
  • Nootropic Agents / chemical synthesis*
  • Nootropic Agents / chemistry

Substances

  • Lactams
  • Lignans
  • Nootropic Agents
  • clausenamide