Abstract
Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the indirect actions of IL-6 that may cause muscle wasting.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Cachexia / blood
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Cachexia / etiology
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Cachexia / metabolism*
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Exercise / physiology
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Glycogen / metabolism
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Humans
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Hypertrophy
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Inflammation / blood
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Inflammation / metabolism
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Interleukin-6 / blood
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Interleukin-6 / metabolism*
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Muscle, Skeletal / metabolism*
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Neoplasms / complications
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Risk Factors
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Signal Transduction