Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link

Am J Surg Pathol. 2010 Nov;34(11):1723-7. doi: 10.1097/PAS.0b013e3181f17d51.

Abstract

Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. Recent cytogenetic studies have shown a t(1;10)(p22;q24) or der(10)t(1;10) in combination with aberrations of chromosome 3 in a limited number of cases of both entities. Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3. This hybrid lesion provides further evidence for a close relationship between these 2 tumor types.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ankle
  • Biopsy
  • Chromosome Aberrations
  • Chromosomes, Human*
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 3
  • Female
  • Fibrosarcoma / genetics*
  • Fibrosarcoma / pathology
  • Fibrosarcoma / radiotherapy
  • Fibrosarcoma / surgery
  • Hemosiderosis / genetics*
  • Hemosiderosis / pathology
  • Hemosiderosis / radiotherapy
  • Hemosiderosis / surgery
  • Humans
  • Karyotyping
  • Lipoma / genetics*
  • Lipoma / pathology
  • Lipoma / radiotherapy
  • Lipoma / surgery
  • Magnetic Resonance Imaging
  • Neoadjuvant Therapy
  • Orthopedic Procedures
  • Radiotherapy, Adjuvant
  • Soft Tissue Neoplasms / genetics*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / radiotherapy
  • Soft Tissue Neoplasms / surgery
  • Translocation, Genetic
  • Treatment Outcome