Abstract
Plasmodium falciparum malaria developed in an African-born traveler who returned to Canada after visiting Nigeria. While there, she took artesunate prophylactically. Isolates had an elevated 50% inhibitory concentration to artemisinin, artesunate, and artemether, compared with that of other African isolates. Inappropriate use of artemisinin derivatives can reduce P. falciparum susceptibility.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Africa
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Antimalarials / administration & dosage
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Antimalarials / pharmacology
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Antimalarials / therapeutic use*
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Artemisinins / administration & dosage
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Artemisinins / pharmacology
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Artemisinins / therapeutic use*
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Artesunate
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Canada
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Chemoprevention*
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Female
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Humans
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Inhibitory Concentration 50
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Malaria, Falciparum / parasitology
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Malaria, Falciparum / prevention & control*
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Nigeria
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Self Medication / adverse effects*
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Travel*
Substances
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Antimalarials
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Artemisinins
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Artesunate