Malignant peripheral nerve sheath tumour in the liver of a dog

J Comp Pathol. 2011 Feb-Apr;144(2-3):223-6. doi: 10.1016/j.jcpa.2010.08.009. Epub 2010 Sep 27.

Abstract

A 14-year-old male mixed breed dog was presented for abdominal distension and abdominal pain. Radiographical examination identified a large space-occupying mass in the abdomen. Necropsy examination revealed the presence of a 12cm hepatic mass that occupied almost half of the abdominal cavity. Microscopically, this mass consisted of spindle-shaped neoplastic cells that were arranged in short streams and interlacing bundles. Immunohistochemically, the neoplastic cells expressed vimentin, S-100, protein gene product 9.5 and neuron specific enolase, but were negative for cytokeratin, smooth muscle actin, melan A and von Willebrand Factor. These findings indicated that the hepatic mass was a primary hepatic peripheral nerve sheath tumour. To our knowledge, this is the first documentation of a primary hepatic malignant peripheral nerve sheath tumour in a dog.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dog Diseases / metabolism
  • Dog Diseases / pathology*
  • Dogs
  • Fatal Outcome
  • Immunohistochemistry / veterinary
  • Liver / metabolism
  • Liver / pathology*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • Liver Neoplasms / veterinary*
  • Male
  • Nerve Sheath Neoplasms / metabolism
  • Nerve Sheath Neoplasms / pathology
  • Nerve Sheath Neoplasms / veterinary*
  • Phosphopyruvate Hydratase / metabolism
  • S100 Proteins / metabolism
  • Vimentin / metabolism

Substances

  • S100 Proteins
  • Vimentin
  • Phosphopyruvate Hydratase