Abstract
The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (-)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abdominal Pain / chemically induced
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Abdominal Pain / drug therapy*
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Acute Disease
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Analgesics / pharmacology
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Analgesics / therapeutic use*
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Behavior, Animal / drug effects*
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Colon / drug effects
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Cyclophosphamide
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Dermatitis / drug therapy*
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Disease Models, Animal
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Ear
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Male
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Mice
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Monocyclic Sesquiterpenes
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Mustard Plant
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Oils, Volatile / chemistry
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Peritoneum / drug effects
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Oils
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use*
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Skin / drug effects
Substances
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Analgesics
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Anti-Inflammatory Agents
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Monocyclic Sesquiterpenes
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Oils, Volatile
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Plant Extracts
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Plant Oils
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Sesquiterpenes
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bisabolol
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Cyclophosphamide
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mustard oil