S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides

J Comb Chem. 2010 Nov 8;12(6):850-4. doi: 10.1021/cc1001023. Epub 2010 Sep 29.

Abstract

The construction of a library of benzothiaoxazepine-1,1'-dioxides utilizing a one-pot, S(N)Ar diversification-ODCT(50) scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Combinatorial Chemistry Techniques / methods
  • Molecular Structure
  • Oxazepines / chemistry*
  • Oxides / chemistry*
  • Small Molecule Libraries* / chemical synthesis
  • Thiazoles / chemistry*

Substances

  • Oxazepines
  • Oxides
  • Small Molecule Libraries
  • Thiazoles