The authors report a 9-day old neonate from a rural area with umbilical myiasis caused by fly larvae of Cochliomyia hominivorax. The blowfly causing this infestation belongs to the family Calliphoridae (Diptera) and the genus Cochliomyia that usually infests only open wounds of animals. The new-world screw-worm fly Cochliomyia hominivorax, is an obligate ectoparasite of domestic and wild animals, and in some cases may affect humans. This is the rare reported case of neonatal umbilical myiasis with sepsis in the world literature.