Cytotoxic pyridone alkaloids from the leaves of Piper aborescens

C Y Duh; Y C Wu; S K Wang

doi:10.1021/np50072a030

Cytotoxic pyridone alkaloids from the leaves of Piper aborescens

J Nat Prod. 1990 Nov-Dec;53(6):1575-7. doi: 10.1021/np50072a030.

Authors

C Y Duh¹, Y C Wu, S K Wang

Affiliation

¹ School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.

PMID: 2089124
DOI: 10.1021/np50072a030

Abstract

Bioactivity-guided fractionation of a CHCl3 extract of the leaves of Piper aborescens afforded a new cytotoxic pyridone alkaloid, N-(3-methoxy-4,5-methylenedioxydihydrocinnamoyl)-delta 3-pyridin-2-one [1], as well as three known cytotoxic pyridone alkaloids, N-(3-methoxy-4,5-methylenedioxycinnamoyl)-delta 3-pyridin-2-one [2], piplartine [3], and piplartine dimer A [4].

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Antineoplastic Agents, Phytogenic* / isolation & purification
Drug Screening Assays, Antitumor
Humans
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Pyridones / isolation & purification
Pyridones / pharmacology*
Tumor Cells, Cultured

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Pyridones