Abstract
Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Atherosclerosis / genetics
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Atherosclerosis / metabolism
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Atherosclerosis / pathology
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Endothelial Cells / metabolism
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Endothelium, Vascular / metabolism
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Gene Expression Regulation
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Hemodynamics / physiology*
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Humans
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Kruppel-Like Transcription Factors / genetics
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Kruppel-Like Transcription Factors / metabolism*
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Shear Strength
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Stress, Mechanical*
Substances
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Kruppel-Like Transcription Factors