RETRACTED: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells

Pramod P Mehta; Pei-Pei Kung; Shinji Yamazaki; Marlena Walls; Andrea Shen; Leslie Nguyen; Michael R Gehring; Gerrit Los; Tod Smeal; Min-Jean Yin

doi:10.1016/j.canlet.2010.09.002

RETRACTED: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells

Cancer Lett. 2011 Jan 1;300(1):30-9. doi: 10.1016/j.canlet.2010.09.002.

Authors

Pramod P Mehta¹, Pei-Pei Kung, Shinji Yamazaki, Marlena Walls, Andrea Shen, Leslie Nguyen, Michael R Gehring, Gerrit Los, Tod Smeal, Min-Jean Yin

Affiliation

¹ Pfizer Worldwide Research and Development, Oncology Research, 10724 Science Center Drive, San Diego, CA 92121, United States.

PMID: 20926183
DOI: 10.1016/j.canlet.2010.09.002

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Authors. Following an investigation by Pfizer, Figures 2, 5B and 5C appear to be duplications and hence the conclusions in the manuscript cannot be verified. The Authors apologize for this inconvenience.

Publication types

Retracted Publication

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation
Extracellular Signal-Regulated MAP Kinases / metabolism
Female
HSP90 Heat-Shock Proteins / antagonists & inhibitors*
Humans
Melanoma / drug therapy*
Melanoma / pathology
Mice
Mutation
Phosphorylation
Proto-Oncogene Proteins B-raf / genetics
Proto-Oncogene Proteins c-akt / metabolism

Substances

Antineoplastic Agents
HSP90 Heat-Shock Proteins
BRAF protein, human
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-akt
Extracellular Signal-Regulated MAP Kinases