A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level

Go Muto; Yuko Takahashi; Hiroyuki Yamashita; Akio Mimori

doi:10.1007/s10165-010-0361-z

A patient with intravascular lymphoma presenting with cerebral infarction and a high serum MPO-ANCA level

Mod Rheumatol. 2011 Apr;21(2):207-10. doi: 10.1007/s10165-010-0361-z. Epub 2010 Oct 8.

Authors

Go Muto¹, Yuko Takahashi, Hiroyuki Yamashita, Akio Mimori

Affiliation

¹ Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

PMID: 20931273
DOI: 10.1007/s10165-010-0361-z

Abstract

A 74-year-old woman presented with multiple brain infarctions, an inflammatory reaction, and a high serum titer (414 U/ml) of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA) with no hematological abnormalities. After the inflammation and ANCA titers were resolved with steroid therapy for suspected microscopic polyangiitis, hemophagocytic syndrome developed. Biopsies revealed non-Hodgkin's intravascular lymphoma (IVL). The flare of IVL with negative serum ANCA suggested that the initial high serum MPO-ANCA had not originated from tumor cells.

Publication types

Case Reports

MeSH terms

Aged
Antibodies, Antineutrophil Cytoplasmic / analysis
Antibodies, Antineutrophil Cytoplasmic / blood*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cerebral Infarction / blood
Cerebral Infarction / diagnosis*
Cerebral Infarction / drug therapy
Diagnosis, Differential
Fatal Outcome
Female
Glucocorticoids / administration & dosage
Glucocorticoids / therapeutic use
Humans
Lymphohistiocytosis, Hemophagocytic / diagnosis
Lymphoma / blood
Lymphoma / diagnosis*
Lymphoma / drug therapy
Peroxidase / immunology*
Vascular Neoplasms / blood
Vascular Neoplasms / diagnosis*
Vascular Neoplasms / drug therapy

Substances

Antibodies, Antineutrophil Cytoplasmic
Glucocorticoids
Peroxidase