Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

Zenya J Brown; José N Nobrega; Suzanne Erb

doi:10.1016/j.bbr.2010.09.025

Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

Behav Brain Res. 2011 Mar 1;217(2):472-6. doi: 10.1016/j.bbr.2010.09.025. Epub 2010 Oct 7.

Authors

Zenya J Brown¹, José N Nobrega, Suzanne Erb

Affiliation

¹ Centre for the Neurobiology of Stress, University of Toronto Scarborough, Toronto, ON, Canada.

PMID: 20933023
DOI: 10.1016/j.bbr.2010.09.025

Abstract

We recently reported that central injections of noradrenaline (NA) induce reinstatement of cocaine seeking in rats. Here, we replicate and extend our finding to an additional dose of NA and show that it is associated with the induction of c-fos mRNA expression (a marker of neuronal activation) in functionally relevant brain regions, including the bed nucleus of the stria terminalis and central nucleus of the amygdala.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amygdala / drug effects*
Animals
Cocaine / administration & dosage*
Conditioning, Operant / drug effects
Corticotropin-Releasing Hormone / analogs & derivatives
Corticotropin-Releasing Hormone / antagonists & inhibitors
Corticotropin-Releasing Hormone / pharmacology
Dose-Response Relationship, Drug
Drug-Seeking Behavior / drug effects*
Injections, Intraventricular / methods
Male
Norepinephrine / administration & dosage*
Nucleus Accumbens / drug effects
Proto-Oncogene Proteins c-fos / genetics*
Proto-Oncogene Proteins c-fos / metabolism
RNA, Messenger / metabolism*
Rats
Rats, Long-Evans
Reinforcement, Psychology*
Self Administration / methods
Septal Nuclei / drug effects

Substances

Proto-Oncogene Proteins c-fos
RNA, Messenger
phenylalanyl corticotropin-releasing factor (12-41)
Corticotropin-Releasing Hormone
Cocaine
Norepinephrine