Abstract
This unit describes the testing of sexual behaviors of male Wistar rats. The described test enables the detection of stimulatory and inhibitory profiles of compounds. The test includes four training sessions to reach a stable sexual performance, followed by acute and/or chronic administration of drugs. The main quantifiable sexual behaviors are number of mounts (no vaginal penetration), intromissions (vaginal penetration), and ejaculations. By comparing the test compound to reference compound(s), sexual (side) effects can be determined.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Copulation / drug effects
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Copulation / physiology
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Disease Models, Animal
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Drug Evaluation, Preclinical / methods*
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Female
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Genitalia, Male / drug effects
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Genitalia, Male / innervation
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Genitalia, Male / physiopathology
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Male
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Rats
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Rats, Wistar
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Selective Serotonin Reuptake Inhibitors / adverse effects
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Selective Serotonin Reuptake Inhibitors / toxicity
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Serotonin / physiology
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Sexual Behavior, Animal / drug effects*
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Sexual Behavior, Animal / physiology
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Sexual Dysfunction, Physiological / chemically induced*
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Sexual Dysfunction, Physiological / physiopathology*
Substances
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Serotonin Uptake Inhibitors
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Serotonin