Abstract
To study chemical constituents of the leaves of Nauclea officinalis, eight alkaloids were isolated from 95% ethanol extract by various chromatographic methods. The structures were elucidated on the basis of spectroscopic data (IR, UV, ESI-MS, 1D and 2D NMR) and identified as naucleactonin C (1), strictosamide (2), vincosamide (3), pumiloside (4), angustoline (5), angustine (6), 18, 19-dihydroangustine (7) and naucleofficine D (8). Compound 1 is a new indole alkaloid. Compounds 6 and 7 were isolated from this plant for the first time.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Camptothecin / analogs & derivatives
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Camptothecin / chemistry
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Camptothecin / isolation & purification
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indoles / chemistry
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Indoles / isolation & purification
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Molecular Structure
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Rubiaceae / chemistry*
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Vinca Alkaloids / chemistry
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Vinca Alkaloids / isolation & purification
Substances
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18,19-dihydroangustine
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Alkaloids
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Indole Alkaloids
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Indoles
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Vinca Alkaloids
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naucleactonin C
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pumiloside
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strictosamide
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angustoline
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angustine
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Camptothecin