Unusual inverse temperature dependence on reaction rate in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes

J Am Chem Soc. 2010 Nov 3;132(43):15104-7. doi: 10.1021/ja103204w.

Abstract

Observations of an intriguing inverse temperature dependence on reaction rate and a profound induction period in the Soai autocatalytic reaction are reported along with detailed kinetic and NMR investigations of the product alkoxide at low temperatures, leading to the suggestion that the active catalyst is derived in situ from the tetrameric ground state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkylation
  • Catalysis
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Pyrimidines / chemistry*
  • Temperature*

Substances

  • Aldehydes
  • Pyrimidines
  • pyrimidine