Immunogenicity of a DNA vaccine of Avian Reovirus orally delivered by attenuated Salmonella typhimurium

Res Vet Sci. 2011 Dec;91(3):382-3. doi: 10.1016/j.rvsc.2010.09.007. Epub 2010 Oct 13.

Abstract

This study aimed to assess the ability of a Salmonella typhimurium-mediated Avain Reovirus DNA vaccine in eliciting antibody production. Six-day-old SPF chickens were orally immunized with SL7207 (pVAX-σC) twice at 2-week interval, detectable antibody was generated 2 weeks after immunization and was significantly higher than the control groups (P<0.01) and ten chickens (66.7%) were considered safe in the subsequent challenge. These results show that SL7207 (pVAX-σC) can induce protective antibody in chickens and the newly-constructed vaccine is also effective in protection chickens against ARV infection.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Chickens*
  • Orthoreovirus, Avian / immunology*
  • Poultry Diseases / prevention & control*
  • Poultry Diseases / virology
  • Reoviridae Infections / prevention & control
  • Reoviridae Infections / veterinary*
  • Salmonella typhimurium / genetics*
  • Specific Pathogen-Free Organisms
  • Vaccines, Attenuated / immunology
  • Vaccines, DNA / administration & dosage
  • Vaccines, DNA / immunology
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / immunology*

Substances

  • Vaccines, Attenuated
  • Vaccines, DNA
  • Viral Vaccines