Fatal invasive trichosporonosis due to Trichosporon loubieri in a patient with T-lymphoblastic lymphoma

Med Mycol. 2011 Apr;49(3):306-10. doi: 10.3109/13693786.2010.525758. Epub 2010 Oct 18.

Abstract

This study describes the third known human case of an invasive infection caused by Trichosporon loubieri. The 21-year-old patient was suffering from a third relapse of T-lymphoblastic lymphoma and had been in pancytopenia for three months when she developed a blood trichosporonosis. The patient died 10 days later, despite intravenous voriconazole therapy. Final unequivocal identification of the strain was done using molecular biology tools.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / administration & dosage
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Fatal Outcome
  • Female
  • Fungemia / diagnosis*
  • Fungemia / drug therapy
  • Humans
  • Immunocompromised Host
  • Molecular Sequence Data
  • Mycoses / diagnosis*
  • Mycoses / drug therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Pyrimidines / administration & dosage
  • Sequence Analysis, DNA
  • Triazoles / administration & dosage
  • Trichosporon / isolation & purification*
  • Voriconazole
  • Young Adult

Substances

  • Antifungal Agents
  • DNA, Fungal
  • DNA, Ribosomal Spacer
  • Pyrimidines
  • Triazoles
  • Voriconazole

Associated data

  • GENBANK/HM585351
  • GENBANK/HM585352