Correlation between vancomycin and daptomycin MIC values for methicillin-susceptible and methicillin-resistant Staphylococcus aureus by 3 testing methodologies

Rebecca A Keel; Christina A Sutherland; Jaber Aslanzadeh; David P Nicolau; Joseph L Kuti

doi:10.1016/j.diagmicrobio.2010.08.006

Correlation between vancomycin and daptomycin MIC values for methicillin-susceptible and methicillin-resistant Staphylococcus aureus by 3 testing methodologies

Diagn Microbiol Infect Dis. 2010 Nov;68(3):326-9. doi: 10.1016/j.diagmicrobio.2010.08.006.

Authors

Rebecca A Keel¹, Christina A Sutherland, Jaber Aslanzadeh, David P Nicolau, Joseph L Kuti

Affiliation

¹ Center for Anti-Infective Research and Development, Hartford, CT 06102, USA.

PMID: 20955917
DOI: 10.1016/j.diagmicrobio.2010.08.006

Abstract

We examined the potential correlation between vancomycin and daptomycin MIC for 298 Staphylococcus aureus by broth microdilution (BMD), Etest, and MicroScan(®). Etest and BMD identified a significant, albeit poor, correlation between MICs (ρ = 0.29, P < .01, and ρ = 0.15, P = .01, respectively), but no correlation (ρ = 0.08, P = .18) was observed with MicroScan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Daptomycin / pharmacology*
Humans
Microbial Sensitivity Tests
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
Vancomycin / pharmacology*

Substances

Anti-Bacterial Agents
Vancomycin
Daptomycin