General and mild preparation of 2-aminopyridines

Org Lett. 2010 Nov 19;12(22):5254-7. doi: 10.1021/ol102301u. Epub 2010 Oct 19.

Abstract

A general and facile one-pot amination procedure for the synthesis of 2-aminopyridines from the corresponding pyridine-N-oxides is presented as a mild alternative to S(N)Ar chemistry. A variety of amines and heterocyclic-N-oxides participate effectively in this transformation which uses the phosphonium salt, PyBroP, as a means of substrate activation.

MeSH terms

  • Amination
  • Amines / chemistry*
  • Aminopyridines / chemical synthesis*
  • Aminopyridines / chemistry
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Organophosphorus Compounds / chemistry
  • Pyridines / chemistry*

Substances

  • Amines
  • Aminopyridines
  • Organophosphorus Compounds
  • Pyridines
  • pyridine N-oxide
  • alpha-aminopyridine