Abstract
A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Catalysis
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Cyclization
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Molecular Sequence Data
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Molecular Structure
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Peptide Hydrolases / chemistry
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Peptides / chemistry*
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Ribosomes / chemistry*
Substances
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Peptides
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Peptide Hydrolases