Abstract
A new sesquiterpene coumarin, gumosin (1), two new sesquiterpene coumarin glycosides, gumosides A (2) and B (3), and 10 known compounds, namely, cauferoside (4), feselol (5), conferoside, ferilin, ferocaulidin, ligupersin A, conferol, and daucosterol, and the phenolic compounds acantrifoside E and 4-hydroxybenzoic acid 4-(6-O-sulfo)glucopyranoside, were isolated from a methanolic extract of Ferula gumosa roots. The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Drug Screening Assays, Antitumor
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Ferula / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Iran
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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Glycosides
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Sesquiterpenes
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gumoside A
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gumoside B
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gumosin