Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis

Chem Commun (Camb). 2010 Dec 14;46(46):8746-8. doi: 10.1039/c0cc02700f. Epub 2010 Oct 21.

Abstract

Fluorescence screening of a 96-membered SPOT library of histidine containing dendritic and linear peptides revealed the remarkable esterolytic activity of short histidine oligomers that show catalytic proficiencies within one order of magnitude of histidine-containing esterase peptide dendrimers.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis*
  • Dendrimers / chemistry*
  • Esterases / chemistry*
  • Esterases / metabolism*
  • Fluorescence*
  • Histidine / chemistry
  • Hydrolysis
  • Molecular Structure
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Array Analysis*

Substances

  • Dendrimers
  • Peptides
  • Histidine
  • Esterases