Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions

Biotechnol Bioeng. 2011 Mar;108(3):720-3. doi: 10.1002/bit.22967. Epub 2010 Nov 11.

Abstract

Coating surfaces with N-alkylated polyethylenimines (PEIs), namely branched N,N-hexyl,methyl-PEI via covalent attachment to glass or linear N,N-dodecyl,methyl-PEI by physical deposition ("painting") onto polyethylene, enables the resultant materials to quickly and efficiently disinfect aqueous solutions of (non-enveloped) poliovirus and rotavirus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Coated Materials, Biocompatible / chemistry
  • Coated Materials, Biocompatible / pharmacology*
  • Disinfectants / pharmacology*
  • Hydrophobic and Hydrophilic Interactions
  • Microbial Viability / drug effects*
  • Poliovirus / drug effects*
  • Polyamines / chemistry
  • Polyamines / pharmacology*
  • Polyelectrolytes
  • Rotavirus / drug effects*
  • Virus Inactivation*

Substances

  • Coated Materials, Biocompatible
  • Disinfectants
  • Polyamines
  • Polyelectrolytes
  • polycations