Abstract
Two novel indole C-glycosides, which were the first reported alkaloids C-glycosides from Isatis indigotica, together with five known alkaloids were isolated. The novel alkaloids were elucidated to be indole-3-acetonitrile-4-methoxy-2-C-β-D-glucopyranoside (1) and N-methoxy-indole-3-acetonitrile-2-C-β-D-glucopyranoside (2) on the basis of spectroscopic analysis. 1 exhibited significant cytotoxic activities against human myeloid leukemia HL-60 and human liver cancer HepG2 cells with the IC(50) of 1.3 ± 0.1 and 2.1 ± 0.3 μM, respectively. 2 showed potential cytotoxic activities against HL-60 and human myeloid leukemia Mata cells with the IC(50) of 5.1 ± 0.4 and 12.1 ± 0.8 μM, respectively.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line, Tumor
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Glucosides
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Humans
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology*
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Isatis / chemistry*
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Leukemia / drug therapy*
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Liver Neoplasms / drug therapy*
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Molecular Structure
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Roots
Substances
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Antineoplastic Agents, Phytogenic
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Glucosides
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Glycosides
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Indoles
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N-methoxy-indole-3-acetonitrile-2-C-beta-D-glucopyranoside
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Plant Extracts
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indole-3-acetonitrile-4-methoxy-2-C-beta-D-glucopyranoside