Abstract
Extracts of a marine Pseudoalteromonas sp. (CMMED 290) isolated from the surface of a nudibranch collected in Kaneohe Bay, Oahu, displayed significant antimicrobial activity against methicillin-resistant Staphylococcus aureus. Bioassay-guided fractionation of the lipophilic extract led to the isolation and structure elucidation of two new highly brominated compounds, 2,3,5,7-tetrabromobenzofuro[3,2-b]pyrrole (1) and 4,4',6-tribromo-2,2'-biphenol (2). In addition, we have identified the known compounds pentabromopseudilin and bromophene. We describe the isolation and structure elucidation of the compounds 1 and 2 together with their antimicrobial activities against methicillin-resistant Staphylococcus aureus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Candida albicans / drug effects
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Drug Screening Assays, Antitumor
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Escherichia coli / drug effects
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Humans
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Hydrocarbons, Brominated / chemistry
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Hydrocarbons, Brominated / isolation & purification*
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Hydrocarbons, Brominated / pharmacology*
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Marine Biology
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Methicillin Resistance / drug effects
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology*
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Pseudoalteromonas / chemistry*
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology*
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects
Substances
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2,3,5,7-tetrabromobenzofuro(3,2-b)pyrrole
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4,4',6-tribromo-2,2'-biphenol
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Anti-Bacterial Agents
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Antineoplastic Agents
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Hydrocarbons, Brominated
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Phenols
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Pyrroles