The inhibition of hepatic microsomal drug metabolism in rats by non-steroidal anti-inflammatory drugs

Pharmacol Res. 1990 Sep-Oct:22 Suppl 3:115-6. doi: 10.1016/s1043-6618(09)80055-8.

Authors

R Gasperini¹, R Leone, G P Velo, M E Fracasso

Affiliation

¹ Institute of Pharmacology, University of Verona, Italy.

PMID: 2097621
DOI: 10.1016/s1043-6618(09)80055-8

No abstract available

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System / metabolism
In Vitro Techniques
Male
Microsomes, Liver / drug effects
Microsomes, Liver / metabolism*
Pharmaceutical Preparations / metabolism*
Protein Denaturation
Rats
Rats, Inbred Strains

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cytochrome P-450 Enzyme Inhibitors
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System