Abstract
The safety and reactogenicity profiles of the 10-valent pneumococcal conjugate vaccine, PHiD-CV, and 7vCRM were comparable within the Philippines and Poland when coadministered as a booster dose with DTPw-HBV/Hib and poliovirus vaccines to toddlers primed with the same vaccines. Robust immune responses for all 10 vaccine pneumococcal serotypes and protein D following PHiD-CV booster vaccination were indicative of effective priming.
Trial registration:
ClinicalTrials.gov NCT00547248.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage*
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
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Haemophilus Vaccines / administration & dosage*
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Haemophilus Vaccines / adverse effects*
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Hepatitis B Vaccines / administration & dosage*
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Hepatitis B Vaccines / adverse effects*
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Immunization, Secondary
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Infant
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Pneumococcal Vaccines / administration & dosage*
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Pneumococcal Vaccines / adverse effects*
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Poliovirus Vaccine, Inactivated / administration & dosage*
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Vaccines, Combined / administration & dosage
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / adverse effects
Substances
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10-valent pneumococcal vaccine
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DTPa-HBV-IPV combined vaccine
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Diphtheria-Tetanus-Pertussis Vaccine
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DtwP-HepB-Hib vaccine
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Haemophilus Vaccines
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Hepatitis B Vaccines
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Vaccines, Combined
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Vaccines, Conjugate
Associated data
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ClinicalTrials.gov/NCT00547248