Essential thrombocythemia: a retrospective study on the clinical course of 100 patients

Haematologica. 1990 Nov-Dec;75(6):537-40.

Abstract

We report a study concerning 100 patients affected by essential thrombocythemia: 90 adult (age greater than 20 years) and 10 pediatric subjects. The diagnosis was made by chance (78%), because of hemorrhages (10%), thrombosis (9%), vasomotor symptoms (29%). In the adult group, single-agent chemotherapy was performed with good remission using pipobroman or interferon. Antiaggregant agents were used in all patients at diagnosis. During the clinical course only a few complications occurred.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Busulfan / therapeutic use
  • Child
  • Child, Preschool
  • Hemorrhagic Disorders / etiology
  • Humans
  • Hydroxyurea / therapeutic use
  • Interferon Type I / therapeutic use
  • Italy / epidemiology
  • Leukemia / etiology
  • Middle Aged
  • Pipobroman / therapeutic use
  • Platelet Aggregation Inhibitors / therapeutic use
  • Recombinant Proteins
  • Retrospective Studies
  • Thrombocythemia, Essential / complications
  • Thrombocythemia, Essential / drug therapy
  • Thrombocythemia, Essential / epidemiology*
  • Thromboembolism / etiology
  • Thromboembolism / prevention & control

Substances

  • Interferon Type I
  • Platelet Aggregation Inhibitors
  • Recombinant Proteins
  • Pipobroman
  • Busulfan
  • Hydroxyurea