[Results of treatment of Hodgkin's disease in children. Observation of 203 cases treated with modified MVPP regimen combined with local radiotherapy]

Pol Tyg Lek. 1990 Dec;45(51-52):1037-41.
[Article in Polish]

Abstract

Totally 209 children were treated within 1971-1982. Complete remission was achieved in 95.6%. Recurrence was noted in 36 patients (18.6%); 20 patients (9.9%) died due to progression of the disease and 9 patients (4.4%) because of complications. The first remission remains constantly in 150 patients for 63-206 months, including that after completion of therapy during 45-206 months. Asymptomatic 5- and 10-year survivals are the following: 82.9% and 80.1% respectively; 5- and 10-year survivals 91.9% and 89.8%, respectively. Expanded experience served as base to design a new regimen (introduced in 1988) which is being supposed to reduce untoward reaction by decreasing the number of MVPP cycles and irradiation doses.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Combined Modality Therapy
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / mortality
  • Hodgkin Disease / radiotherapy*
  • Humans
  • Mechlorethamine / administration & dosage
  • Prednisolone / administration & dosage
  • Procarbazine / administration & dosage
  • Recurrence
  • Remission Induction
  • Survival Rate
  • Vinblastine / administration & dosage

Substances

  • Procarbazine
  • Mechlorethamine
  • Vinblastine
  • Prednisolone

Supplementary concepts

  • MVPP protocol