Susceptibility of several species of Candida and Torulopsis to fluconazole and ketoconazole

Drugs Exp Clin Res. 1990;16(10):509-13.

Abstract

The authors compared the in vitro antifungal activity of fluconazole, a new triazole antifungal agent, and ketoconazole, an imidazole derivative. The MIC values were determined against 50 strains of Candida albicans, 10 strains of C. guilliermondii, 10 strains of C. krusei, 10 strains of C. parapsilosis, 10 strains of C. pseudotropicalis, 10 strains of C. tropicalis and 15 strains of Torulopsis glabrata. The fungistatic activity was evaluated by the agar dilution method using BHI and casitone media after incubation for 48 h at 28-30 degrees C. Both antifungal agents showed higher activity when tested on casitone medium; however, the G-MIC values for ketoconazole were lower than those for fluconazole.

Publication types

  • Comparative Study

MeSH terms

  • Candida / drug effects*
  • Fluconazole / pharmacology*
  • Ketoconazole / pharmacology*
  • Microbial Sensitivity Tests

Substances

  • Fluconazole
  • Ketoconazole