Abstract
Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Evolution, Molecular
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Viral / physiology
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Hemagglutinins / genetics*
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Humans
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Influenza A Virus, H1N1 Subtype / genetics*
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Influenza, Human / epidemiology
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Influenza, Human / virology
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Models, Molecular
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Neuraminidase / genetics*
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Pandemics*
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Phylogeny
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Polymorphism, Genetic
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Reassortant Viruses / genetics*
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viral Proteins / metabolism
Substances
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Hemagglutinins
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Viral Proteins
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Neuraminidase