Abstract
The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The structural and functional properties that are characteristic of the ligand family provide a basis for possible evolutionary relationships among the various ligands.
MeSH terms
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Amino Acid Sequence
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Amphiregulin
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Animals
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EGF Family of Proteins
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Epidermal Growth Factor / metabolism
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Epidermal Growth Factor / physiology
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ErbB Receptors / metabolism
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ErbB Receptors / physiology*
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Glycoproteins / metabolism
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Glycoproteins / physiology
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Growth Substances / metabolism
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Growth Substances / physiology*
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Humans
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Intercellular Signaling Peptides and Proteins*
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Ligands
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Molecular Sequence Data
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Transforming Growth Factor alpha / metabolism
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Transforming Growth Factor alpha / physiology
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Viral Proteins / metabolism
Substances
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AREG protein, human
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Amphiregulin
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EGF Family of Proteins
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Glycoproteins
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Ligands
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Transforming Growth Factor alpha
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Viral Proteins
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Epidermal Growth Factor
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ErbB Receptors