Abstract
There is growing evidence in the scientific literature for shared risk and overlapping disease mechanisms in the development of cancer and Parkinson disease (PD). This association has recently been highlighted with respect to melanoma and PD. Therefore, we review and discuss the literature concerning this unexplained link. A striking overlap is observed in the tyrosine and L-dopa biosynthetic pathways suggesting a common disease mechanism associated with these 2 heterogeneous disorders that warrants further investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Brain Neoplasms / etiology
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Brain Neoplasms / metabolism
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Brain Neoplasms / pathology*
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Group VI Phospholipases A2 / genetics
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Humans
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Levodopa / metabolism
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Melanoma / genetics*
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Melanoma / metabolism
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Melanoma / pathology*
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Neural Pathways / metabolism
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Neural Pathways / pathology
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Parkinson Disease / pathology*
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Tyrosine / metabolism
Substances
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Tyrosine
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Levodopa
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Group VI Phospholipases A2
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PLA2G6 protein, human