Abstract
This paper describes a detailed study of tumour necrosis factor release during the immediate post transplant period in recipients of liver and kidney allografts. The results show no correlation between levels of TNF and rejection in Azathioprine and steroid treated patients and give good correlation in cyclosporin A immunosuppressed patients. Treatment with monoclonal antibody Campath 1-G caused high levels of TNF production. Interleukin-1 levels were not associated with levels of TNF. Sequential measurements of TNF levels may provide an aid to early diagnosis of graft rejection.
MeSH terms
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal / therapeutic use
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Azathioprine / pharmacology
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Azathioprine / therapeutic use
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Cyclosporins / pharmacology
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Cyclosporins / therapeutic use
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Diagnosis, Differential
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Graft Rejection*
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Humans
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Infections / diagnosis
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Interleukin-1 / blood
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Kidney Transplantation / immunology*
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Liver Transplantation / immunology*
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Pancreas Transplantation / immunology
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Steroids / pharmacology
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Steroids / therapeutic use
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Tumor Necrosis Factor-alpha / analysis*
Substances
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Antibodies, Monoclonal
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Cyclosporins
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Interleukin-1
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Steroids
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Tumor Necrosis Factor-alpha
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Azathioprine