Abstract
A polyaromatic alkaloid, aplidiopsamine A was isolated from the temperate Australian ascidian, Aplidiopsis confluata, and its structure was determined from interpretation of mass, 1D and 2D NMR spectra. Aplidiopsamine A is the first alkaloid to possess the tricyclic aromatic substructure 3H-pyrrolo[2,3-c]quinoline conjugated to an adenine. Aplidiopsamine A exhibited significant inhibition of growth of chloroquine resistant and sensitive strains of the malaria parasite, Plasmodium falciparum, and minimal toxicity toward human cells.
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Antimalarials / chemistry*
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Australia
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / isolation & purification
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Pyrroles
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Quinolines
Substances
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Alkaloids
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Antimalarials
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Plant Extracts
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Pyrroles
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Quinolines
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aplidiopsamine A