Abstract
Dopamine (DA) and serotonin (5-HT) transporter availability in heroin users and healthy controls was measured using [¹²³I]β-CIT and SPECT imaging. Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Brain / diagnostic imaging*
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Brain / pathology
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Brain Mapping
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Chronic Disease
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Cocaine / analogs & derivatives
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Dopamine / metabolism*
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Female
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Heroin Dependence* / diagnostic imaging
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Heroin Dependence* / metabolism
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Heroin Dependence* / pathology
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Humans
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Magnetic Resonance Imaging / methods
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Male
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Middle Aged
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Radiopharmaceuticals
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Serotonin Plasma Membrane Transport Proteins / metabolism*
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Tomography, Emission-Computed, Single-Photon*
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Young Adult
Substances
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Radiopharmaceuticals
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Serotonin Plasma Membrane Transport Proteins
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2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
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Cocaine
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Dopamine