Abstract
The identification of novel orally active mGluR5 antagonist GSK2210875 is described.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Administration, Oral
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Allosteric Regulation
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Animals
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Brain / drug effects
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Brain / metabolism
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Heterocyclic Compounds, 3-Ring / chemical synthesis
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Heterocyclic Compounds, 3-Ring / chemistry*
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Heterocyclic Compounds, 3-Ring / pharmacokinetics
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Mice
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Rats
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Receptors, Metabotropic Glutamate / metabolism
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Structure-Activity Relationship
Substances
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GSK2210875
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Grm5 protein, mouse
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Grm5 protein, rat
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Heterocyclic Compounds, 3-Ring
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate