Abstract
This chapter describes the manufacturing process to a certain level for a possible oligonucleotide cargo and a peptide API in a multi-kilogram scale from a manufacture's point of view. In the concluding remarks, possible conjugation methods will be discussed from an industrial-scale perspective.
MeSH terms
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Cell-Penetrating Peptides / chemical synthesis*
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Cell-Penetrating Peptides / chemistry
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Cell-Penetrating Peptides / isolation & purification
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Cell-Penetrating Peptides / metabolism*
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Chromatography, High Pressure Liquid
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Chromatography, Reverse-Phase
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Drug Carriers / chemical synthesis*
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Drug Carriers / chemistry
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Drug Carriers / isolation & purification
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Drug Carriers / metabolism*
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Drug Industry*
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Fluorenes / chemistry
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Indicators and Reagents / chemistry
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Oligonucleotides / chemical synthesis*
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Oligonucleotides / chemistry
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Oligonucleotides / isolation & purification
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Oligonucleotides / metabolism*
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Resins, Synthetic / chemistry
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Solvents / chemistry
Substances
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9-fluorenylmethoxycarbonyl
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Cell-Penetrating Peptides
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Drug Carriers
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Fluorenes
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Indicators and Reagents
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Oligonucleotides
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Resins, Synthetic
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Solvents