Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation

Pediatr Transplant. 2012 Mar;16(2):E39-42. doi: 10.1111/j.1399-3046.2010.01408.x. Epub 2010 Nov 5.

Abstract

TA-TMA is a serious complication of hematopoietic stem cell transplantation, presenting as microangiopathic hemolytic anemia with severe renal injury and mortality as high as 60%. Diagnosis and treatment of TA-TMA is very challenging after HSCT because anemia, thrombocytopenia, hypertension, and renal impairment are multifactorial, leading to delayed recognition and management of this complication. We report a successful outcome following early intervention for hyperacute TA-TMA after allogeneic HSCT.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Early Medical Intervention*
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Leukemia, Myeloid, Acute / surgery*
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / therapy
  • Thrombotic Microangiopathies / diagnosis*
  • Thrombotic Microangiopathies / etiology
  • Thrombotic Microangiopathies / therapy